A Conceptual Model for CO2-induced Redistribution of Cerebral Blood Flow with Experimental Confirmation using BOLD MRI
O Sobczyk, A Battisti-Charbonney, J Fierstra, D M Mandell, J Poublanc, A P Crawley, D J Mikulis, J Duffin, J A Fisher. Neuroimage. 2014 May 15;92:56-68. doi: 10.1016/j.neuroimage.2014.01.051. Epub 2014 Feb 5.
Cerebrovascular reactivity (CVR) is the change in cerebral blood flow (CBF) in response to a change in a vasoactive stimulus. Paradoxical reductions in CBF in response to vasodilatory stimulation (‘steal’) are associated with vascular pathology. However, a pathophysiological interpretation of ‘steal’ requires a comprehensive conceptual model linking pathology and changes in blood flow. Herein, we extend a simple model explaining steal published in the late 1960s by incorporating concepts of CBF regulation from more recent studies to generate a comprehensive dynamic model.