RespirAct™

Gas Control System

Thornhill Medical - Research

Controls blood gases non-invasively to stimulate vascular reactivity.

RespirAct™ RA-MR stimulates blood flow responses in organs such as the brain and heart by precisely controlling arterial PCO2 and PO2. Monitoring the blood flow responses in conjunction with diagnostic imaging techniques such as MRI reveals aspects related to a subject’s vascular health.

 

 

RespirAct™
Research Enquiries

Current RespirAct™ User?
More info here


RespirAct™ CAPABILITIES

Generates Consistent and Standardized Stimulus

RespirAct ™ RA-MR is a computer-controlled gas blender to implement precise control of PCO2 and PO2 for a consistent and repeatable stimulus.

Compatible with an MRI Environment

MRI Conditional – A portion of the system remains in the control room and communicates with a unit which is placed next to the MRI bed. RespirAct ™ RA-MR can also be used with Transcranial Doppler (TCD) and other imaging modalities.

Cited in 150+ Articles Published in Peer Reviewed Journals

Used by 45+ elite research institutions globally, contributing to 2/3 of all RespirAct™ cited publications.

Simple and Intuitive User Interface

RespirAct ™ RA-MR is controlled through a user-friendly graphical interface requiring minimum training.

Safety

RespirAct ™ RA-MR is designed with fail safes and there is no potential of inadvertent hypoxic gas administration

Specifications

Thornhill Medical - Research

Independent control of blood gases · Targeting of PCO2 and PO2 is independent of each other · Range of PCO2 targeting: 25 - 70 mmHg · Range of PO2 targeting: 70 - 700 mmHg*. PO2 as low as 40mmHg can be achieved if required

Thornhill Medical - Research

Choose from multiple blood gas targeting patterns that are built-in: · Box car · Continuous Ramp · Sinusoidal · Combination of above · Accuracy within 2 mmHg of target for PCO2 · Transitions in PCO2 and PO2 can often be achieved in 1-3 breathes, under many circumstances within 1 breath

Thornhill Medical - Research

The following gas mixtures are required: • Gas A: 10% O2, 90% N2 • Gas B: 10% O2, 90% CO2 • Gas C: 100% O2 • Calibration Gas: 10% O2, 9% CO2, 81% N2 We suggest that you order K size cylinders for Gas A, B and C and a E size cylinder for Calibration gas. If “wall Oxygen” is available, it can replace Gas C. Secure cylinders as per your local regulations.

Important Note

IMPORTANT NOTE:  RespirAct ™ RA-MR has not been evaluated by the FDA and is distributed by Thornhill Medical to collaborators for use in IRB approved basic physiological research studies. The RespirAct ™ RA-MR system is not intended to be used in the diagnosis or treatment of disease and is not intended to be used in studies that evaluate its safety or efficacy. More details can be found on the RespirAct ™ RA-MR Forum.

Important Note

IMPORTANT NOTE:  RespirAct ™ RA-MR has not been evaluated by the FDA and is distributed by Thornhill Medical to collaborators for use in IRB approved basic physiological research studies. The RespirAct ™ RA-MR system is not intended to be used in the diagnosis or treatment of disease and is not intended to be used in studies that evaluate its safety or efficacy. More details can be found on the RespirAct ™ RA-MR Forum.

RESPIRACT™ RESOURCES

The CO2 stimulus for cerebrovascular reactivity: Fixing inspired concentrations vs. targeting end-tidal partial pressures.
The CO2 stimulus for cerebrovascular reactivity: Fixing inspired concentrations vs. targeting end-tidal partial pressures.

Read more
Magnetic Resonance Imaging–Based Cerebrovascular Reactivity and Hemodynamic Reserve: A Review of Method Optimization and Data Interpretation
Magnetic Resonance Imaging–Based Cerebrovascular Reactivity and Hemodynamic Reserve: A Review of Method Optimization and Data Interpretation

Read more
Assessing cerebrovascular reactivity abnormality by comparison to a reference atlas.
Assessing cerebrovascular reactivity abnormality by comparison to a reference atlas.

Read more