RespirAct™ RA-MR stimulates blood flow responses in organs such as the brain and heart by precisely controlling arterial PCO2 and PO2. Monitoring the blood flow responses in conjunction with diagnostic imaging techniques such as MRI reveals aspects related to a subject’s vascular health.
RespirAct ™ RA-MR is a computer-controlled gas blender to implement precise control of PCO2 and PO2 for a consistent and repeatable stimulus.
MRI Conditional – A portion of the system remains in the control room and communicates with a unit which is placed next to the MRI bed. RespirAct ™ RA-MR can also be used with Transcranial Doppler (TCD) and other imaging modalities.
Used by 45+ elite research institutions globally, contributing to 2/3 of all RespirAct™ cited publications.
RespirAct ™ RA-MR is controlled through a user-friendly graphical interface requiring minimum training.
RespirAct ™ RA-MR is designed with fail safes and there is no potential of inadvertent hypoxic gas administration
Independent control of blood gases · Targeting of PCO2 and PO2 is independent of each other · Range of PCO2 targeting: 25 - 70 mmHg · Range of PO2 targeting: 70 - 700 mmHg*. PO2 as low as 40mmHg can be achieved if required
Choose from multiple blood gas targeting patterns that are built-in: · Box car · Continuous Ramp · Sinusoidal · Combination of above · Accuracy within 2 mmHg of target for PCO2 · Transitions in PCO2 and PO2 can often be achieved in 1-3 breathes, under many circumstances within 1 breath
The following gas mixtures are required: • Gas A: 10% O2, 90% N2 • Gas B: 10% O2, 90% CO2 • Gas C: 100% O2 • Calibration Gas: 10% O2, 9% CO2, 81% N2 We suggest that you order K size cylinders for Gas A, B and C and a E size cylinder for Calibration gas. If “wall Oxygen” is available, it can replace Gas C. Secure cylinders as per your local regulations.
IMPORTANT NOTE: RespirAct ™ RA-MR has not been evaluated by the FDA and is distributed by Thornhill Medical to collaborators for use in IRB approved basic physiological research studies. The RespirAct ™ RA-MR system is not intended to be used in the diagnosis or treatment of disease and is not intended to be used in studies that evaluate its safety or efficacy. More details can be found on the RespirAct ™ RA-MR Forum.
IMPORTANT NOTE: RespirAct ™ RA-MR has not been evaluated by the FDA and is distributed by Thornhill Medical to collaborators for use in IRB approved basic physiological research studies. The RespirAct ™ RA-MR system is not intended to be used in the diagnosis or treatment of disease and is not intended to be used in studies that evaluate its safety or efficacy. More details can be found on the RespirAct ™ RA-MR Forum.
